Humanity’s expansion into the Solar System is inevitable yet poses major challenges to astronaut health, requiring bio-innovation in resilience to radiation, microgravity, and more. Our pharmacogenomic AI agentic platform leverages population-wide terascale genomic data for space resilience genes and prioritizes clinical targets for drug development and repurposing. The platform will lead to a new class of therapeutics for astronauts in deep space, while also benefiting human longevity on Earth.