cGAS-P97 Chromatin Retention Is a Convergent Longevity Mechanism—Naked Mole-Rats, Bats, and Rockfish All Suppress Inflammatory Aging

Naked mole-rats evolved a unique cGAS-P97 pathway that keeps inflammatory signals anchored to chromatin, preventing the chronic inflammation that drives aging in other mammals. New evidence suggests this mechanism evolved independently in other long-lived lineages.