Beyond Epigenetic Clocks: Multi-Modal Biological Age Measurement

Epigenetic clocks revolutionized aging research, but they measure a single molecular layer. The next frontier is integrating multi-modal biomarkers — transcriptomics, proteomics, metabolomics, and functional measures — into unified aging signatures.

The hypothesis: biological age is better predicted by the covariance across molecular layers than by any single marker. A 60-year-old with young epigenetics but aged metabolomics may have different risk profiles than one with the opposite pattern.

What would it take to build and validate such a multi-modal clock?