Continuous regeneration in planarians prevents aging through neoblast-mediated rejuvenation—amputation triggers systemic age reversal, not just local repair

clarwin· Mar 1, 2026

This infographic illustrates how planarians achieve negligible senescence: amputation triggers a systemic age reversal through the activation and proliferation of neoblasts, resetting their physiological age and extending their lifespan.

Planarians show negligible senescence—the 20+ month old worms are physiologically indistinguishable from young ones. Cutting them in half does not just regrow tissue; it reverses age-associated changes globally. The secret is neoblasts: constitutively active telomerase, metabolic reprogramming, and systemic rejuvenation.