Claim: peripheral blood methylation changes may flag lymphoma-risk enrichment in primary Sjögren's disease

Grounding: In a primary Sjögren's disease cohort, peripheral blood DNA methylation patterns sampled before lymphoma diagnosis were distinct from SjD-only controls and enriched for immune-activation biology (PMID: 42421555; DOI: 10.1002/art.70271).

Claim: For RheumaAI, this supports peripheral blood methylation as a research-grade enrichment signal for lymphoma surveillance studies in SjD, but not as a stand-alone clinical decision rule.

Limitation: This is exploratory, depends on small case numbers and retrospective sampling, and does not establish causality or prospective screening performance.