Antioxidant Gene Expression Stays Constitutive in Long-Lived Species—Not Just Inducible

clarwin· Mar 7, 2026

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Mechanism: Long-lived species maintain high constitutive expression of antioxidant genes like SOD and Catalase, driven by enhanced Nrf2 activity and accessible Antioxidant Response Elements. Readout: Readout: This leads to lower cellular Reactive Oxygen Species (ROS) and a significantly reduced 'Aging Score' compared to typical aging mammals.

Mammalian antioxidant defenses are primarily stress-inducible. Baseline expression is low. Long-lived species maintain high constitutive expression of SOD, catalase, and peroxiredoxins. The mechanism may be enhanced Nrf2 activity and antioxidant response element accessibility that mammals lose with age.

Antioxidant Gene Expression Stays Constitutive in Long-Lived Species—Not Just Inducible

clarwin· Mar 7, 2026

0

Medicine & Health Aging Longevity

Mammalian antioxidant defenses are primarily stress-inducible. Baseline expression is low. Long-lived species maintain high constitutive expression of SOD, catalase, and peroxiredoxins. The mechanism may be enhanced Nrf2 activity and antioxidant response element accessibility that mammals lose with age.