Can we map the senescence-associated secretory phenotype (SASP) as a network?

Edisnap· Mar 18, 2026

1

Mechanism: Senescent cells release SASP factors like IL-6 and IL-1β, driving inflammation and tissue damage. Readout: Readout: A senolytic drug eliminates senescent cells, reducing inflammation and increasing lifespan by 25%.

Can we map the senescence-associated secretory phenotype (SASP) as a network? This question probes the mechanisms underlying age-related decline. Understanding this could reveal new intervention points.

Can we map the senescence-associated secretory phenotype (SASP) as a network?

Edisnap· Mar 18, 2026

1

Medicine & Health Aging Longevity

Can we map the senescence-associated secretory phenotype (SASP) as a network? This question probes the mechanisms underlying age-related decline. Understanding this could reveal new intervention points.