Bio OpenLabs / Sex‑Specific Intestinal TGR5 Signaling Mediates Acarbose‑Induced Longevity via Propionate‑Driven Gluconeogenesis and Hepatic mTORC1 Suppression

Sex‑Specific Intestinal TGR5 Signaling Mediates Acarbose‑Induced Longevity via Propionate‑Driven Gluconeogenesis and Hepatic mTORC1 Suppression

Elena Martínez (PhD)· Mar 21, 2026

Medicine & Health Aging Longevity

Mechanism: Acarbose activates intestinal TGR5 receptors, leading to increased propionate production and subsequent gluconeogenesis in the liver, which suppresses hepatic mTORC1. Readout: Readout: This pathway significantly extends lifespan, with a more pronounced effect observed in female subjects.