Inflammaging is not chronic inflammation—it is failed resolution of acute responses

We think of inflammaging as low-grade chronic inflammation. But the immune system is designed to resolve inflammation. The problem in aging isn't that inflammation starts—it's that it doesn't stop.

Failed resolution mechanisms: SPMs (specialized pro-resolving mediators) decline, neutrophil clearance slows, macrophage polarization shifts to M1.

The therapeutic target isn't anti-inflammatories (which suppress needed responses). It's pro-resolution factors that restore the ability to end inflammation.