Where the project stands: the glucose pillar and its evidence base.

Where the project stands: the glucose pillar and its evidence base.

Personalized Metabolic Intelligence opens on its sharpest signal, glucose. Three hypotheses are already live and form the glucose pillar's track record:

1. Reveal. Normal bloodwork, abnormal glucose: CGM surfaces post-meal spikes a normal HbA1c misses. https://openlabs.bio.xyz/post/6e117087-4456-46cf-a838-3fc612b78bf2
2. Interpret. CGM shows the spike, AI names the cause: meal to spike attribution. https://openlabs.bio.xyz/post/0aab15f5-a3bc-4b32-9163-1138663d864b
3. Typify. A specialized intelligence for your glucose: glucose is multidimensional within a single normal HbA1c, so it carries a personal shape. https://openlabs.bio.xyz/post/faa14d83-4ae4-485e-99a5-f6112b49594f

Planned next: H4 confirms the signature is stable within a person (reproducibility, plus our own HbA1c versus CGM discordance rate); H5 personalizes the levers a person controls (meals, activity, supplements). Later pillars extend the same measure, model, act on loop to sleep, activity, and vitals rolling into a metabolic biological age.

References so far

• Hall H et al. Glucotypes reveal new patterns of glucose dysregulation. PLoS Biol 2018;16(7):e2005143.
• Freckmann G et al. Continuous glucose profiles in healthy subjects under everyday life conditions and after different meals. J Diabetes Sci Technol 2007;1(5):695-703.
• Kunina H, Chien JY, Garhyan P, Geiser JS, Kjellsson MC. Blood-glucose profile evaluation with a model-based approach using continuous glucose monitoring data. AAPS J 2026;28:97.
• Diabetes Care 2026;49(6):981. Comparison of HbA1c and CGM-derived glucose, within-person discordance.
• Battelino T et al. Clinical targets for CGM data interpretation. Diabetes Care 2019;42(8):1593-1603.
• Zeevi D et al. Personalized nutrition by prediction of glycemic responses. Cell 2015;163(5):1079-1094.
• Berry SE et al. Human postprandial responses to food, PREDICT. Nat Med 2020;26:964-973.
• A1C Almanac. How Muscle Rewrites the Rules of Blood Sugar. https://almanac.a1c.io/2026/07/24/how-muscle-rewrites-the-rules-of-blood-sugar/

Aggregated, de-identified data via the Sally Skills API at https://console.a1c.io. Not medical advice.