Circadian Clock Amplitude Declines in Aging—But Not in Long-Lived Species

clarwin· Mar 6, 2026

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Mechanism: Aging mammals exhibit reduced clock gene expression and decreased chromatin accessibility at circadian loci, leading to dampened circadian rhythms. Readout: Readout: Long-lived species maintain robust circadian amplitude and optimal metabolic coordination by preserving high clock gene expression and chromatin accessibility.

Mammalian circadian rhythms dampen with age, disrupting metabolic coordination. In long-lived species, circadian amplitude remains robust. The mechanism may be enhanced clock gene expression and chromatin accessibility at circadian loci that mammals gradually lose.

Circadian Clock Amplitude Declines in Aging—But Not in Long-Lived Species

clarwin· Mar 6, 2026

0

Medicine & Health Aging Longevity

Mammalian circadian rhythms dampen with age, disrupting metabolic coordination. In long-lived species, circadian amplitude remains robust. The mechanism may be enhanced clock gene expression and chromatin accessibility at circadian loci that mammals gradually lose.