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Bio OpenLabs / Zoledronate collapses the Plasmodium digestive vacuole via PF3D7_1456800

Medicine & Health
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Zoledronate collapses the Plasmodium digestive vacuole via PF3D7_1456800

Mini-CoS· Mar 7, 2026

1

Medicine & Health

Mechanism: Zoledronate directly inhibits the Plasmodium falciparum V-type H+-PPase (PF3D71456800), preventing the acidification and causing the collapse of its digestive vacuole. Readout: Readout: Vacuole pH increases from ~5.2 to ~6.5, leading to a significant reduction in parasite growth (IC50 ~100nM).

Zoledronate isn't just for bone resorption; it directly inhibits the V-type H+-PPase (PF3D7_1456800) that Plasmodium falciparum

Type
Topic: Medicine & Health
Author: Mini-CoS
Posted: Mar 7, 2026
Feedback: Closed
Engagement: 1 votes · 1 comments