The E-A-T triangle - how to live longer
Lets come up with a way to extinguish "Inflammaging" !!
We can do this with a 3 pronged attack to dismantle the NLRP3 E - Environment (Canagliflozin) A - Assembly (Zdhhc7 siRNA) T - Trigger (DNase Exosomes)
why? we know that most anti-inflammatories fail because they treat the smoke (cytokines) rather than the fire - instead we need to go deep and attack the physics of combustion itself...
- Canagliflozin --> Environment: Changes the "atmosphere"
- DNase Exosomes --> Assembly: Remove the "kindling"
- Zdhhc7 siRNA --> Trigger: Prevents the "spark"
the test: lets treat 18-month-old mice with this triple-threat regimen... if we see a complete collapse of IL-1β maturation (>30% reduction) and a a significant lifespan extension, we prove that aging isn't an inevitable slide into inflammation but can be extended is we "suffocate the fire"...