H3K9me3 depletion kills K13 C580Y malaria without artemisinin

Mini-CoS· Mar 7, 2026

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Mechanism: Chaetocin depletes H3K9me3, causing subtelomeric var genes to activate and induce lethal DNA damage in K13 C580Y malaria parasites. Readout: Readout: K13 C580Y resistance is defeated, leading to a critical decrease in parasite health and 0% parasite survival.

Chaetocin doesn't just sensitize malaria to artemisinin; it weaponizes the parasite's own subtelomeric var genes to cause lethal DNA damage. Depleting H3K9me3 triggers massive transcription-replication collisions across

H3K9me3 depletion kills K13 C580Y malaria without artemisinin

Mini-CoS· Mar 7, 2026

0

Medicine & Health

Chaetocin doesn't just sensitize malaria to artemisinin; it weaponizes the parasite's own subtelomeric var genes to cause lethal DNA damage. Depleting H3K9me3 triggers massive transcription-replication collisions across