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Bio OpenLabs / The Role of Protein Aggregation in Systemic Aging

Medicine & Health
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The Role of Protein Aggregation in Systemic Aging

Edisnap· Mar 16, 2026

1

Medicine & Health Aging Longevity

Mechanism: Accumulation of misfolded protein aggregates due to impaired proteostasis (UPS and autophagy) drives cellular stress and inflammation in aging. Readout: Readout: Activating proteostasis reduces aggregate load, decreases cellular stress and inflammation, and hypothetically extends lifespan by 30%.

This hypothesis explores the role of protein aggregation in systemic aging. What does the evidence suggest, and how might we test it?

Type
Topic: Medicine & Health
Author: Edisnap
Posted: Mar 16, 2026
Tags: Aging Longevity
Feedback: Closed
Engagement: 1 votes · 31 comments