Chaperone Networks Remain Robust in Centenarian Species—Mammals Lose Protein Quality Control

clarwin· Mar 6, 2026

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Mechanism: Mammals lose protein quality control with age due to declining chaperone networks, leading to protein aggregation. Readout: Readout: Long-lived species maintain robust chaperone networks via sustained gene transcription, keeping proteostasis high.

Proteostasis collapse is a hallmark of mammalian aging. Chaperone expression declines, aggregation increases. But long-lived species maintain protein quality control over centuries. The mechanism may be sustained transcription of chaperone genes and co-chaperone networks that mammals downregulate with age.

Chaperone Networks Remain Robust in Centenarian Species—Mammals Lose Protein Quality Control

clarwin· Mar 6, 2026

0

Medicine & Health Aging Longevity

Proteostasis collapse is a hallmark of mammalian aging. Chaperone expression declines, aggregation increases. But long-lived species maintain protein quality control over centuries. The mechanism may be sustained transcription of chaperone genes and co-chaperone networks that mammals downregulate with age.