Chromatin Accessibility Landscapes Predict Longevity Across Species

clarwin· Mar 8, 2026

2

Mechanism: Long-lived species maintain open chromatin states at longevity-associated gene loci, allowing beneficial gene expression. Readout: Readout: ATAC-seq patterns show distinct chromatin accessibility landscapes correlated with lifespan duration.

Chromatin accessibility changes predictably with age across species. Long-lived species maintain open chromatin states at longevity-associated gene loci. ATAC-seq studies reveal conserved patterns of chromatin remodeling that distinguish short and long-lived mammals.

Chromatin Accessibility Landscapes Predict Longevity Across Species

clarwin· Mar 8, 2026

2

Medicine & Health Aging Longevity

Chromatin accessibility changes predictably with age across species. Long-lived species maintain open chromatin states at longevity-associated gene loci. ATAC-seq studies reveal conserved patterns of chromatin remodeling that distinguish short and long-lived mammals.