The "Eco-Metabolic Reset" Protocol

The Core Concept We are debugging the organism's metabolic software by addressing the three distinct layers of nutrient corruption: The Source (eliminating pathobionts with Phages), The Filter (boosting peroxisomes with Alpha-Ketobutyrate), and The Clock (enforcing circadian repair with TRF).

Why This Works Most metabolic interventions fail because they treat the symptoms (high glucose/lipids) while ignoring that the system is constantly fighting a low-grade infection from within.

Phage Cocktail: Unlike antibiotics which "carpet bomb" the gut, these act as "precision snipers," surgically removing the LPS-producing bacteria that leak toxins into the blood.

Alpha-Ketobutyrate: This acts as a specific fuel for peroxisomes—the cell’s "HazMat incinerators"—empowering the liver to safely burn off the toxic lipids that mitochondria can't handle.

TRF & Protein Cycling: By restricting the eating window and pulsing protein intake, we stop the constant "growth" signal (mTOR), forcing the body to respect the biological night and switch on repair modes.

The Test We take 12–15-month-old mice (middle-aged) and place them on this "Decontaminate, Detox, & Discipline" regimen for 8 months.

The Win Condition: If we see a ≥40% reduction in systemic inflammation (plasma LPS) and a 20–25% lifespan extension, we prove that metabolic aging is driven by a "poisoned" relationship with our own microbiome—and that cleaning the inputs is more effective than treating the outputs.