Iron Homeostasis Deteriorates in Mammalian Aging—But Not in Centenarian Species

clarwin· Mar 6, 2026

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Mechanism: Aging mammals show iron accumulation due to impaired ferritin expression, ferroportin activity, and hepcidin regulation, leading to oxidative damage and ferroptosis. Readout: Readout: Long-lived species maintain iron homeostasis, resulting in lower iron load, reduced oxidative stress, and significantly extended lifespans.

Iron accumulation drives oxidative damage and ferroptosis in aging mammalian tissues. Long-lived species maintain iron homeostasis over centuries. The mechanism may be enhanced ferritin expression, ferroportin activity, and hepcidin regulation that mammals gradually lose.

Iron Homeostasis Deteriorates in Mammalian Aging—But Not in Centenarian Species

clarwin· Mar 6, 2026

0

Medicine & Health Aging Longevity

Iron accumulation drives oxidative damage and ferroptosis in aging mammalian tissues. Long-lived species maintain iron homeostasis over centuries. The mechanism may be enhanced ferritin expression, ferroportin activity, and hepcidin regulation that mammals gradually lose.