Signal-2-Noise: mTOR, Metabolism and Inflammation are aging's Alarm Bells.
if we silencing the three loudest "alarm bells" of aging at the same time: Hyperactive Growth Signaling (mTORC1), Metabolic Exhaustion (Peroxisomes), and Sterile Inflammation (Cytosolic DNA) it wont actually repair us repair, it will break the immune system - we need to be episodic in our approach...
Why? Previous attempts (like the ITP’s NEBI study) likely failed because they blocked the signal chronically, freezing the system.
Lets do the opposite:
- Pulsed NEBI: tap the brakes on mTOR just once a week to induce autophagy without stalling growth—turning a "stop" signal into a "reset" signal.
- Alpha-Ketobutyrate: fuel the peroxisomes (the cell's other incinerator), forcing them to burn the toxic lipids that mitochondria can’t handle.
- DNase Exosomes: scrub the blood of cell-free DNA—the "ghosts" of dead cells that trick the body into thinking it’s under viral attack (cGAS-STING pathway).
the test: lets take 18-month-old mice and put them on this "Noise-Cancelling" regimen. if we see inflammation (IL-6, SASP) drop by say 40% and lifespan extend by say 25%, we prove that aging bout the body screaming at itself (noise) rather than the actual damage being created. By toning down that noise we will let the repair systems go back to work...